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    • 专利摘要:
    Chinese herbal extracts of edible Taiwan, especially plant extracts with melanin production inhibitory, elastase inhibitory, hyaluronidase inhibitory, free radical scavenging and radical scavenging antioxidant activity, and medically acceptable skin and A skin anti-aging composition containing an additive. The composition is useful for promoting whitening, maintaining skin tension and elasticity, enhancing moisturizing to the skin, and imparting anti-inflammatory and antiallergic action to the skin.
    公开号:KR20030061847A
    申请号:KR10-2003-7007906
    申请日:2001-12-10
    公开日:2003-07-22
    发明作者:치바가츠요시；소네도시로；미야자키고우지；하나미즈도모코；니시사카후키코；마츠모토사치코；아이야마리츠오
    申请人:가부시끼가이샤 야구르트혼샤；
    IPC主号:
    专利说明:

    Skin anti-aging composition {COMPOSITION FOR RETARDING SKIN AGING}
    [2] In the case of melanin suppression, in order to prevent phenomena and freckles caused by blackening, inflammation and pigmentation of the skin caused by sunburn or the like for external skin preparations for whitening, or to alleviate increased pigmentation, Whitening agents such as ascorbic acid or its derivatives, placenta extract, kojic acid, glutathione, hydroquinone and its derivatives (albutin), and plant extracts have been formulated (Fragrance Journal, 1990, No. 6, pp. 47-58).
    [3] In addition, elastase is a protease that specifically acts on elastin, which is involved in skin tension and elasticity. This is involved in the reduction of elastin, which has a particularly prominent result among skin aging phenomena, and since ultraviolet light activates the action of elastase, the result is that the skin loses tension and elasticity. Since the action of elastase is activated with age and the same result, if the excessive action of the elastase can be suppressed, it is possible to prevent skin aging due to ultraviolet rays or aging. As a result of the search for a substance having an elastase inhibitory activity from this point of view, it was confirmed that extracts such as Schima liukiuensis, eucalyptus, and phyllanthus urinaria were effective (Japanese Patent Laid-Open No. 9-95420). Japanese Patent Laid-Open No. 9-87137, Japanese Patent Laid-Open No. 9-87136).
    [4] In addition, the function of hyaluronic acid in connective tissue is to maintain water in the cell gap or to form a jelly-like matrix in the tissue to maintain the cells, to maintain the lubricity and flexibility of the skin, and to prevent external force (mechanical disorder) and bacterial infection It is thought to prevent. Hyaluronic acid in the skin decreases with age, and as a result, it causes aging, such as fine wrinkles and fluttering. Therefore, suppressing the activity of hyaluronidase that decomposes this hyaluronic acid is thought to contribute to the stabilization of hyaluronic acid present in the skin, and is also thought to be effective in improving skin aging and deterioration of skin barrier function. . This is also considered to contribute to the stability of hyaluronic acid used for the treatment of arthritis and the stability of hyaluronic acid in the formulations applied to the skin for the purpose of improving the deterioration of skin function.
    [5] In addition, hyaluronidase is also known as an inflammatory enzyme (inflammatory trigger), and it is known that inhibiting its activity inhibits inflammation and also inhibits allergy. Several substances that inhibit the activity of hyaluronidase have been reported, and herbal extracts include peony root, coccitis rhizome (Japanese Patent Application Laid-open No. Hei 1-128933), geranium herb. (Japanese Patent Laid-Open No. 2-11520), Mimusops elengi, Eugenia jambolana, Saraca indica, Cinnamon lamp, Seonhakcho ), And Japanese hydration (Japanese Patent Laid-Open No. Hei 6-80553) have been confirmed to inhibit hyaluronidase.
    [6] Active enzyme scavenger with SOD action is caused by various diseases caused by free radicals (O 2 − ), such as diseases caused by blood flow disorders (myocardial infarction, stroke, high blood pressure, menstrual pain, stiff neck, neuralgia, back pain, hangover, etc.), It is widely used in the treatment and improvement of adult diseases and medical diseases (cancer, nephritis, hepatitis, diabetes, etc.), cosmetics and dermatitis (stain, freckles, rough skin, cold diseases, constipation, wrinkles, atopic dermatitis, etc.) , Food additives, cosmetics, medicine and the like.
    [7] Specifically, cosmetic materials (eg, Japanese Patent Application Laid-Open No. 59-10324, Japanese Patent Application Laid-Open No. 55-87712, etc.) utilizing various properties of SOD, placenta or soy extract with stable SOD activity, and a combination thereof The external preparation composition (Japanese Unexamined-Japanese-Patent No. 61-277626) characterized by the above-mentioned is known. In addition, plant extracts with SOD action include mountain migraine, phalanges, injinho, jet lag, Gohwa, night bridge, etc. ), Icho, Bangui, Maddera, Seokchangpo, Golden Pavilion, Ichilobye (Japanese Patent Application Laid-Open No. 8-28317), Hibiscus, Aloe, rhubarb, yellowfin, wushuur, Yeonmyeongcho, wild gardenia, yangmeipi, brown root, shiho, cheongung , Creation (하), peppermint, Fuling (,), licorice, peony (신), shinyi (반 夏), donkey (當歸), cinnamon, ten, yellow lotus, peony, gentian, fivefold, Ivory, cauliflower, ephedra, yellowish white, pedestrian, health, contrast, golden, dermis, turmeric tea, honeysuckle, kyoujitsu, syrup, garlic, sage, oregano, rosemary, laurel leaf, celery, thyme, Tarragon, onion, nutmeg, mace, clove, horseradish, savory, basil, sugar Purple, soybean tea, black tea, green tea, persimmon leaf, coffee, horse mackerel, daikon, sage brush, stain rod, wolfberry, Beef pear, shiitake, ginkgo (Japanese Patent Publication No. Hei 6-24937) or golden, ginkgo, cinnamon Plant extracts containing flavonoids such as back, mountain lion, gugwihwa, rock odor, melissa, dysentery, peony, parsley, trumenchira, nahan, fruit tea and phalanx (Japanese Patent Application No. 10-307680) Publications).
    [8] Sebum is secreted onto human skin in order to protect the skin, and the sebum is oxidized by ultraviolet light or the like to become lipid peroxide, which irritates the skin. In addition, these lipid peroxides attack cell membranes and cause disorders or other adverse effects, and these disorders are known to be involved in human skin aging. Therefore, suppressing the production of lipid peroxide with an antioxidant is considered to be effective not only in preventing deterioration of the skin but also in preventing aging of a living body.
    [9] Among the specific antioxidants, plant extracts include white birch (Betula platyphylla) extract (Japanese Patent Application Laid-open No. Hei 10-46143), hibiscus, aloe, rhubarb, yellow flower, wubarushi, yeonmyeongcho , Yangpipi, reeds, peppermint, licorice, peony, two-in-one, god, cinnamon, ten, yellow lotus, peony, gentian, gallander, savory, sageweed, yellow white, health, golden, spirit, garlic, sage, oregano, Water or water from one or more plants selected from the group consisting of rosemary, laurel leaves, celery, thyme, tarragon, nutmeg, mace, clove, horseradish, oleander, sage brush, vine tea, stain stalk, wolfberry, beef fern, shiitake Various plant extracts (Japanese Patent Laid-Open No. 6-24937) extracted with a lower alcohol or a lower alcohol aqueous solution have been reported.
    [10] However, regarding the production of melanin, the skin external preparations containing these whitening agents may not have sufficient effects of the whitening agent, or may inhibit the production of melanin, but there may be problems in safety or may be altered in the preparation. In many cases, the improvement was desired.
    [11] As regards the inhibition of elastase activity, it is possible to prevent skin aging if the excessive action of elastase can be suppressed. However, conventionally reported elastase inhibitors have not been satisfactory in terms of stability, effectiveness and usability.
    [12] Hyaluronidase deactivation has been searched in various ways for cosmetic raw materials having anti-inflammatory or anti-allergic activity, but a safe and promising one has not yet been obtained. There has been a demand for substances that are natural in terms of safety to human skin, have been ingested by humans for many years, and are safe in terms of safety, have a strong hyaluronidase inhibitory effect, and have other effects on the skin.
    [13] As an active oxygen removing material, there is a superoxide dismutase (SOD) which is an enzyme in vivo, but its purification is difficult, and it is very expensive because it is unstable to heat and easily inert. For this reason, the emergence of the SOD substitute material (SOD type active material) which exhibits the active oxygen removal effect similarly to SOD, and is obtained with high stability and inexpensively is desired.
    [14] As an antioxidant, among the antioxidants used conventionally, cosmetic materials and skin external preparations which mix BHT, BHA, etc. are easy to produce contact dermatitis, and are concerned from a safety point. On the other hand, gallic acid derivatives and vitamin Es do not have sufficient antioxidant activity and cannot effectively prevent rancidity of oil-containing products, and especially in skin external preparations containing these, particularly for peroxidation of skin lipids. In anticipation of anti-aging of the resulting skin, sufficient effects were not obtained.
    [15] Moreover, in the whitening action, in addition to the direct inhibition of melanocytes that synthesize melanin, the production of melanocyte stimulants (MSH, endoserine, NO, histamine, PGE2, etc.) released from cells around melanocytes is suppressed. It is also an important factor. Therefore, the anti-inflammatory action of preventing these stimulants from being released from keratinocytes is thought to be effective in helping whitening.
    [16] In addition, ascorbic acid derivatives and arbutin, which are general whitening agents, have antioxidative action on their own, and it is considered that the action of inhibiting free radicals and free radicals is part of the mechanism of whitening action. From these, as an ingredient of an anti-aging agent, the herbal extract which has each effect, such as whitening, antioxidant, and anti-inflammatory, is more effective. However, until now, the search for the herbal extract which has a plurality of these functions has not been carried out.
    [1] The present invention relates to an anti-aging composition, and more particularly, various herbal extracts having melanin production inhibitory, elastase inhibitory activity, hyaluronidase inhibitory action, active oxygen elimination action and / or radical trapping antioxidant activity. The present invention relates to a composition containing a certain number selected from among the above, wherein the composition is blended into a formulation to promote whitening of the skin, that is, to promote whitening, to maintain the tension and elasticity of the skin, to increase moisturization to the skin, and to It is useful for imparting anti-inflammatory and anti-allergic action.
    [17] An object of the present invention is to provide a skin anti-aging composition that promotes whitening, maintains skin tension and elasticity, increases skin moisturization, and imparts anti-inflammatory and anti-allergic action to the skin. do.
    [18] The anti-aging composition according to one embodiment of the present invention includes a base and / or additives medically acceptable for external skin, crystallized scent (Ludwigia octovalvis), Anisomeles indica, Scutellaria rivularis, anti-slim ( Lobelia chinensis, Urena lobata, Verbena officinalis, Cuscuta australis, Dichondra micrantha, Phyllanthus urinaria, Physalis angulata, Cedar gyn Rorippa indica, Hydrocotyle formosana, Vernonia cinerae, Spilanthes acmella, Canna indica, Ipomoeapes-caprae, Fossil water (Clerodendrum calamitosum), Drosera burmanni, Anoectochilus formosanus, Wikstroemia indica, Ellaeagnus oldhamii, Mussaenda parviflora, Mesona procumbens, Aristolochia mollis (Acorus gramineus), Golden family (Cudrania cochinchinensis var.gerontoge a), Clodendrum philippinum, Daecheong (Clerodendrum cyrtophyllum), White narcissus (Clerodendrum paniculataum var.albifloraum), Boehmeria densiflora, Sapium sebiferum, Tetrastigma dentatumVitis, thunbergii, Bauhinia championi, Bredia oldhami, Stalagyne concinnula, Selaginella doederleinii, Lespedeza cuneata, Lupinwigia hyssopifolia, Heavenlight, etc. japonica, Sphenomeris chusana, Adiantum flabellulatum, Hyptis suaveolens, Kummerowia striata, Cleodendrum trichotomum, Vitex negundo, Xangium strumarium var. japonica, Bidens pilosa var. minor, Gnaphalium affine, Emilia sonchifolia, Mimosa pudica, Euphorbia hirta, Plantago formosana, Cardiospermum halicacabum, Plumbago zeylanica, Torenia concolor var. formosona, Euphorbia formosana, Viola phillippica, Polygonum multiflorum var. hypoleucum, Ficus erecta var beecheyana, Kalanchoe spathulata, Mallothus repandus, Uncaria hirsuta, Rhus semialata var. roxburghiana, Rubia lanceolata, Safflower sageweed coccinea, Ixeris chinensis, Ixeris laevigata var.oldhami, Gordendrum inerme, Hyptis rhomboides, Callicarpa formosana, Yago (Aeginetia indica), Dongcheokdae It is selected from the group consisting of Praia nummularia and Acanthopanax trifoliatus It contains one or two or more plant extracts.
    [19] The anti-aging composition according to another aspect of the present invention has a base and / or additive which is medically allowed for external application of skin and, in particular, anisomeles indica and S. herb (Urena lobata) having melanin production inhibitory effect as an anti-aging effect. ), Cuscuta australis, Dichondra micrantha, Physalis angulata, Cleome gynandra, Rorippa indica, Hydrocotyle formosana, Spillotuses acmella, Beauty Canna indica, Anoectochilus formosanus, Wikstroemia indica, Aristolochia mollis, Acorus gramineus, Cudrania cochinchinensis var.gerontogea, Daecheol (Cleroumdrum cyrtophyll) Bauhinia championi, Selaginella doederleinii, Lespideza cuneata, Ludwigia hyssopifolia, Xanthium strumarium, Bidens pilosa var. Minor, Emilia sonchifolia ), Plantago formosana, Bag Plumbago zeylanica, Torenia concolor var.formosona, Viola phillippica, Milkus (Ficus erecta var.beecheyana), Kalanchoe spathulata, Rubia lanceolata, Safflower Contains one or two or more plant extracts selected from the group consisting of Samicho (Salvia coccinea).
    [20] Anti-aging composition according to another embodiment of the present invention is a base and / or additive medically accepted for external skin, and has an elastase inhibitory effect as an anti-aging effect, Phyllanthus urinaria, Wikstroemia indica, Cudraia cochinchinensis var.gerontogea, Boehmeria densiflora, Tetrastigma dentatum, Vitis thunbergii, Bauhinia championi, Bream oldhami, Hojija (Lespedeza cuneata), cedar clove (Ludwigia hyssopifolia), Adiantum flabellulatum, Mimosa pudica, Cardiospermum halicacabum, Plumbago zeylanica, Torenia concolor var. Formosona, Taiwan It contains one or more plant extracts selected from the group consisting of Polygonum multiflorum var. Hypoleucum, Uncaria hirsuta, and Rhus semialata var. Roxburghiana.
    [21] Anti-aging composition according to another aspect of the present invention is a gold-based (Cudrania cochinchinensis var.gerontogea), which has a base and / or additives medically acceptable for external application of the skin and a hyaluronidase inhibitory effect as an anti-aging effect, It contains one or two or more plant extracts selected from the group consisting of Vitis thunbergii and Bauhinia championi.
    [22] Anti-aging composition according to another aspect of the present invention is a base and / or additives medically acceptable for external skin, and has a free radical removal effect as an anti-aging effect, Ludwigia octovalvis, Anisomeles indica ), Scutellaria rivularis, Lobelia chinensis, Verbena officinalis, Cuscuta australis, Phyllanthus urinaria, Physalis angulata, Cleome gynandra (Vernonia cinerae), Canna indica, Ipomoea pes-caprae, Fossil water (Clerodendrum calamitosum), Drosera burmanni, Wikstroemia indica, Ellaeagnus oldhamii, Jade leaf Goldfinch (Mussaenda parviflora), Sesame (Mesona procumbens), Seokchangpo (Acorus gramineus), Golden family (Cudrania cochinchinensis var. , Necked horse (Boehmeria d ensiflora, Sapium sebiferum, Tetrastigma dentatum, Vegetative grape (Vitis thunbergii), Chrysanthemum (Bauhinia championi), Bredia lodhami, Stataurogyne concinnula, Lespedeza cuneata , Leafwood clove (Ludwigia hyssopifolia), Stellaia japonica, Adiantum flabellulatum, Hyptis suaveolens, Clowndendrum trichotomum, Vitex negundo, Seokchocho (Gnaphalium affine) (Mimosa pudica), yuzacho (Euphorbia hirta), and gore (Torenia concolor var. formosona, Echohorbia formosana, Polygonum multiflorum var. hypoleucum, Moltus repandus, Uncaria hirsuta, Rhus semialata var. roxburghiana, Planatago for mosana, Cardiospermum halicacabum, Rubia lanceolata, Ixeris chinensis, Ixeris laevigata var.oldhami, Cledenden inerme, Hyptis rhomboides, two Contains one or two or more plant extracts selected from the group consisting of safflower (Callicarpa formosana), yago (Aeginetia indica), Prato nummularia, and Acanthopanax trifoliatus.
    [23] Anti-aging composition according to another aspect of the present invention is a base and / or additives medically acceptable for skin external use, antioxidant properties as anti-aging effect, Ludwigia octovalvis, Anisomeles indica, Scutellaria rivularis, Verbena officinalis, Phyllanthus urinaria, Vernonia cinerae, Ipomoea pes-caprae, Drosera burmanni, Wikstroemia indica, White leaf root (Elaeagnus oldhamii), larva (Mussaenda parviflora), vine (Mesona procumbens), Golden family (Cudrania cochinchinensis var. Grape (Tetrastigma dentatum), Vitis thunbergii, Chrysanthemum (Bauhinia championi), Gemini (Bredia lodhami), Staghorn (Staurogyne concinnula), Lespedeza cuneata, Locuswig clove (Ludwigia hyssopifolia) (Sphenomeris chusana), Iron Dirt (Adi antum flabellulatum, Hyptis suaveolena, Kumerowia striata, Clujdendrum trichotomum, Vitex negundo, Euphorbia hirta, Torenia concolor var. formosona Euphorbia formosana, Polygonum multiflorum var.hypoleucum, Milkus (Ficus erecta Var. Beecheyana), Kanghyang repandus, Uncaria hirsuta, Rhus semialata Murp roxburghiana It contains one or two or more plant extracts selected from the group.
    [24] The present invention also provides a cosmetic material and an external skin preparation containing the anti-aging composition.
    [25] The herbal medicine used in the present invention has the herbal medicine name and scientific name shown in the following Table 1a and Table 1b, and various parts of the plant (outpost, flower, head flower, flower water, magnetized water, fruit tree, hull, leaf, eggplant, Ground leaf, rhizome, rhizome, root, seed, etc.) may be used as it is or after being pulverized and extracted with a solvent.
    [26]
    [27]
    [28] The method for producing such a herbal extract is not particularly limited as long as it is a commonly used method. For example, the following method may be used. That is, the crude powder is finely pulverized, and the extraction solvent (water, alcohol, organic solvent or mixture thereof) is added 5-10 times and left at room temperature for at least 1 week, and then the filtrate obtained by filtration is dried and dried. It is taken as an extract. Alternatively, an extract solvent (water or organic solvent) is added to the raw herbal powder, and the filtrate obtained by filtration after heating at a constant temperature or reflux temperature of the solvent is concentrated and dried.
    [29] Specific extraction solvents include aqueous solvents (e.g., water, acidic or basic aqueous solvents), alcohols (e.g., lower alcohols such as methanol, anhydrous ethanol, ethanol, or polyhydric compounds such as propylene glycol and 1,3-butylene glycol). Alcohols, etc.), ketones such as acetone, esters such as diethyl ether, dioxane, acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene, and chloroform may be used alone or in combination of two or more kinds thereof. Can be. In particular, water, methanol, ethanol and 50% ethanol are preferred. It can also be used in a state in which each solvent extract is combined.
    [30] In the present invention, the plant extract may be used as it is, and known bases and / or additives for external skin, such as cosmetic ingredients, such as water, alcohols, Oils, surfactants, preservatives, fragrances, pigments, moisturizers, thickeners, water-soluble polymers, antioxidants, chelating agents, pH adjusters, blowing agents, (pigments, UV absorbers and scattering agents, powders), vitamins, amino acids, antibacterial agents, seaweed Extracts, various drugs, additives and the like can be blended
    [31] Specifically, examples of the oil include macadamia nut oil, castor oil, olive oil, cacao oil, camellia oil, palm oil, beeswax, plant oils such as jojoba oil, grape seed oil, avocado oil, animal oils such as mink oil and egg yolk oil, and beeswax. Waxes such as spermatozoon, lanolin, carnava wax, candelilla wax, liquid paraffin, squalene, microcrystalline wax, selesin wax, paraffin wax, hydrocarbons such as petrolatum, capric acid, myristic acid, palmitic Natural and synthetic fatty acids such as acids, stearic acid, behenic acid, lanolin fatty acids, linoleic acid, linolenic acid, lauric acid, myristic acid, oleic acid, isostearic acid, cetanol, stearyl alcohol, hexyldecanol, octyldodecane Natural and synthetic higher alcohols such as ol, lauryl alcohol, capryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol, isopropyl myristate, isopropyl palmitate, octylate acid octylate, oleic Ester, such as octyl dodecyl phosphate and a cholesterol oleate, etc. can be illustrated.
    [32] Examples of the surfactant include sorbitan monolaurate, sorbitan monopalmitate, sorbitan sorbitan sulphate, sorbitan sorbate trioleate, polyoxyethylene sorbitan monolaurate, polyoxetylene sorbitan monostearate and polyethylene Nonionic such as glycol monooleate, polyethylene glycol alkylate, polyoxyethylene alkyl ether, polyglycol diether, lauroyl diethanol amide, fatty acid isopropanol amide, maltitol hydroxy fatty acid ether, alkylated polysaccharide, alkyl glucoside, sugar ester, etc. Active agent, lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerol monostearate, polyglycerin alkylate, sorbitan monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate, poly Oxyethylene Cetyl Ether, Polyoxye Nonionic surfactants such as sterolized polyol, polyoxyethylenated lanolin, polyoxyethylenated beeswax, polyoxyethylene-cured castor oil, sodium stearate, potassium palmitate, sodium cetyl sulfate, sodium lauryl phosphate, and triethanolamine palmitate , Sodium polyoxyethylene lauryl phosphate, sodium N-acyl glutamate, sodium palmitate, sodium laurate, sodium laurate, potassium lauryl sulfate, alkyl ethanol triethanolamine ether, rod oil, linear dodecylbenzene sulfate, Anionic surfactants such as polyoxyethylene-cured castor oil maleic acid and acylmethyl taurine acid, cationic interfaces such as stearyl dimethylbenzyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, benzalkonium chloride and laurylamine oxide Amphoteric surfactants, such as an active agent, alkylaminoethylglycine chloride, lecithin, etc. can be illustrated.
    [33] Examples of the preservative include benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4 ' -Trichlorocarbanilide, benzalkonium chloride, hinokithiol, resorcin, ethanol and the like can be exemplified.
    [34] Examples of the moisturizing agent include glycerin, erythritol, xylitol, maltitol glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, and isoprene glycol. NMF components such as polyhydric alcohols, amino acids, sodium lactate, sodium pyrrolidone carboxylate, xyloglucan, quince seed, carrageenan, pectin, met, cadmane, galactan, delmantansulfate, glycogen, keratan sulfate, chondroitin , Water-soluble polymers such as mucoitin sulfate, keratosulfate, locust bean gum, succinoglucan, calonym acid, hyaluronic acid, heparan sulfate, sodium hyaluronate, collagen, mucopolysaccharides, chondroitin sulfate, dimethyl Silicones, such as polysiloxane and methylphenylsiloxane, Culture supernatant, such as lactic acid bacteria and bifidus bacteria, etc. can be illustrated.
    [35] Examples of the thickener include sodium alginate, chitantan gum, aluminum silicate, quince seed extract, gum arabic, hydroxyethyl guar gum, carboxymethyl guar gum, guar gum, dextran, tragacanth gum, starch, Natural polymer materials such as chitin, chitosan, carboxymethyl chitin, agar, cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, soluble starch, cationized cellulose, etc. And synthetic polymer materials such as semisynthetic polymer material, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, vinyl alcohol and vinyl acetate copolymer.
    [36] The antioxidant is dibutyl hydroxytoluene, butyl hydroxy anisole, molybdenum propyl, ascorbic acid and the like, the chelating agent is disodium edate, ethylenediamine tetraacetic acid, pyrrole phosphate, hexametharate, quenoic acid, tartaric acid Examples of the pH adjuster include sodium hydroxide, triethanolamine, quenoic acid, sodium quenoate, boric acid, borax, potassium hydrogen phosphate, and the like.
    [37] As said ultraviolet absorber and scattering agent, a paraamino benzoic acid ultraviolet absorber, an anthranilic acid ultraviolet absorber, a salicylic acid ultraviolet absorber, a cinnamic acid ultraviolet absorber, a benzophenone ultraviolet absorber, a sugar ultraviolet absorber, 3- (4'-methylbenzylidene) -d-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenbenzoxazole, 2,2'-hydroxy-5- Methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, dibenzalazine ), Dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, 2-hydroxy-4-methoxy benzophenone, octyl dimethyl para amino benzoate, ethylhexyl para methoxy sinemate, titanium oxide, kaolin, talc etc. can be illustrated.
    [38] The vitamins include vitamin A and its derivatives, vitamin B 6 hydrochloride, vitamin B 6 tripalmitate, vitamin B 6 dioctanoate, vitamin B 2 and its derivatives, vitamin B 12 , vitamin B 15, and derivatives thereof. Vitamin Bs, ascorbic acid, ascorbic acid sulfate and salts thereof, ascorbic acid phosphate esters and salts thereof, ascorbic acid dipalmitate, ascorbic acid glucoside, acyl ascorbic acid glucoside, α-tocophenol, β-tocophenol, Vitamin E, such as γ-tocophenol and vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, vitamin F, vitamin K, vitamin P, vitamin U, carnitine, ferulic acid, γ-orizanol and α-lipoic acid , Orotic acid and derivatives thereof can be exemplified.
    [39] The amino acids include glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, asparagine, glutamine, taurine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, glutamic acid, arginine, and arginine. Histidine, lysine, derivatives thereof, and the like.
    [40] Examples of the antimicrobial agent include benzoic acid, salicylic acid, sorbic acid, paraoxybenzoic acid alkyl ester, and hexachlorophene.
    [41] The seaweed extracts include extracts from brown algae, red algae, green algae and south algae, specifically kelp, kelp, seaweed, sea buckwheat, sea urchin, coral horse, palmaria, sea horse, seaweed, green onion, and green seaweed. , Extracts from Ascophyllum, Fucus, large horse, Okinawa large horse, Himanthalia and the like can be exemplified.
    [42] Examples of the various agents include nicotinic acid amide, nicotinic acid benzyl, γ-orizanol, allantrin, glycyrrhizin acid (salt), glycyrrhetinic acid and derivatives thereof, hinokithiol, bisabolol, eucarpton, thymol, inositol, psychosaponin, Saponins, such as ginseng saponin, a loofah saponin, and a saponin saponin, pantothenyl ethyl ether, ethynyl estradiol, a tranexamic acid, arbutin, a separanthin, a placenta extract, etc. can be illustrated.
    [43] In the present invention, the blending amount of the herbal extract is not particularly limited, and may be appropriately set in accordance with the strength (IC 50 value) and the dosage form of the extract, for example. The blending amount of the herbal extract is preferably 0.0001 to 30% by weight, in particular 0.001 to 10%, in terms of extract solids, based on the total amount of the anti-aging composition.
    [44] Cosmetics, external preparations, quasi-drugs, etc. containing the anti-aging composition according to the present invention can be produced by a conventional method. For example, lotion, milky lotion, moisturizing cream, cleansing cream, massage cream, face cream, pack, cosmetics such as cosmetics, hair products such as shampoo or rinse, bath cosmetics such as bathing agent, makeup cosmetics such as foundation, sunscreen etc. It can be in various forms, such as special cosmetics.
    [45] Next, the present invention will be described in more detail with reference to experimental examples and examples, but the present invention is not limited thereto.
    [46] Experimental Example 1: Preparation of herbal extracts (Namnyeong Yew Yoo extract preparation)
    [47] 1.8L of 100% methanol was added to 282.3 g of Nanling Yew, extracted for 1 week at room temperature, filtered, and the filtrate was evaporated to dryness. The dry weight was 21.49 g (yield 7.6%).
    [48] Hereinafter, about each herbal medicine of Table 1, 1-100OL of 100% methanol was added and extracted with respect to each herbal medicine of Table 1, and each extract was obtained. 100% methanol yield of each extract is shown in Tables 2a and 2b. In addition, the pH of the dried material at 0.5%, the dissolved state and color tone at 0.5% of the solid concentration in the 50% ethanol solution, and the absorbance at 312 nm are also shown in Tables 2A and 2B.
    [49]
    [50]
    [51] * DG: deepgreen, LDG: light deep green, OC: 0live color, LOC: 1ight olive color, YE: yellow, LY: light Light yellow, YB: yellowish brown, LYB: light yellowish brown, BR: brown, RB: reddish brown, LRB: light reddish brown, DB: dark brown, DDB: deep dark brown, BDB: blackish dark brown
    [52] Experimental Example 2 melanin production inhibition and cytotoxicity test
    [53] B16 mouse melanoma cells (B16-F1 cells, ATCC No. CRL-6323) purchased from Dainippon Seiyaku Co., Ltd. were measured by 96 well plate method. The cells (1 × 10 4 ) were seeded in each wel1, and after 24 hours of incubation in D-MEM containing 10% FCS and 1% antibiotic solution (37 ° C., 5% CO 2 ), the medium was tested and theophyrin. (0.5 mM) was added and exchanged with D-MEM, and further cultured for 3 days. In addition, a solvent (ethanol) of the test substance was added to the medium so that the final concentration was 1%. Melanin production inhibitory activity was added to the culture supernatant obtained by centrifugation with an equivalent amount of HEPES buffer (pH6.8) / ethanol (9: 1), and the microplate reader EL-340 (BIO-TEK INSTRUMENT) of 475 nm-66Onm. The absorbance was measured and the amount of extracellular melanin was evaluated. The results are shown in Table 3 below.
    [54] As a result, as shown in Table 3, 31 items of herbal extracts with an inhibition rate of 20% or more at the test concentration of 0.001% were found, in particular, solid, non-leaved grass, Namyeongwha, Seokchangpo, Geomokpo, Echinacea, Changi, White Lantern, Chrysanthemum Tree, Taiwan Madhuyeong, Hampungcho, Golden Chicken, Wild Vegetables, Horseshoe, Milk Dragon, Suksangbaek, Safflower Sumicho, Foliage Flower Designation, IC 50 value (control cell melanin amount of control) Half of the test substance concentration) was 10 μg / mL or less, and a stronger action was confirmed than that of arbutin or kojic acid (Table 3), which was established as a positive control (Table 3). No cytotoxicity was observed at the test concentration of 0.001%.
    [55] Herbal Medicine No.Melanin production inhibitionHerbal Medicine No.Melanin production inhibition % Inhibition at 0.001%IC 50 μg / ml% Inhibition at 0.001%IC 50 μg / ml 10. Gossip104.61.966. Gold Swordweed34.510.9 62. Nonleaflet94.31.951. Prickly pear29.810.9 21. Nanling Yew93.50.01559. Leaf Maple Designation29.110.0 26. Seokchangpo93.12.715. Gold ball26.6- 57. Stop Goku79.54.529. Daecheong26.4- 2. First77.93.011.Hwabchae24.6- 48. Window72.73.139. Hojija22.7- 56. White light70.13.940. cedar clove22.5- 35. Chrysanthemum67.34.613. Letter of Payment22.4- 25. Taiwan Madudo65.54.65. Sludge22.0- 49. Hampungcho64.93.120. Geum Seon Ryun22.0- 27.Golden64.73.816. Beautiful woman21.9- 12. Opening53.38.77. Earthenware21.6- 8. Horseshoe52.88.654. Chajeoncho20.2- 60. For milk51.67.5Sangbaekpi61.93.8 38. Gargoyle39.48.8Arbutin32.412.1 67.Sulfur sulfite34.59.9Kojisan25.712.9
    [56] -: Not measured
    [57] Experimental Example 3: Elastase Inhibition Test
    [58] Synthetic substrate Methoxysuccinyl-Ala-Ala-Ala-Pro-p-nitroanilide (8.0 mM, 25 μl) 25 μl of 0.1 M Hepes buffer (containing pH 7.4, 0.5 M NaCl) containing 5 μg / ml of neutrophil-derived elastase The mixture was reacted with 50 μl at 37 ° C. for 30 minutes, and then the absorbance of 405 nm was measured using a microplate reader EL-340 (BIO-TEK NSTRUMENT). In addition, the enzyme inhibition rate was computed according to the following formula | equation. The results are shown in Table 4 below.
    [59] % Inhibition = (A-B) / A × 10 0
    [60] A; Absorbance at sample addition, B; Absorbance at Sample Addition
    [61] Herbal Medicine No.Elastase inhibitionHerbal Medicine No.Elastase inhibition % Inhibition at 0.025%IC 50 μg / ml% Inhibition at 0.025%IC 50 μg / ml 65. Lassi salted splint66.61.49. Lobe35.4- 34. Leafy Grapes66.59.064. Taiwan lantern34.8- 52. Much sec63.846.021. Nanling Yew34.3- 35. Chrysanthemum61.410.555. To order32.0- 57. Stop Goku60.654.827.Golden30.4- 56. White light58.3-40. cedar clove28.6- 60. Taiwan Shaoshou56.463.843. Iron Monastery28.4- 33. Trifolium Grape56.222.836. Gold pomegranate24.5- 31. Neck52.150.9ELHIBIN29.3- 39. Hojija49.6-
    [62] -: Not measured
    [63] As shown in Table 4, 18 herbal drugs with 20% or more inhibitory activity were found at 0.025% concentration. IC 50 value was lower than that of the product, and strong elastase inhibitory activity was confirmed.
    [64] Experimental Example 4: Hyaluronidase Inhibition Test
    [65] 100 μl of the sample was added to 50 μl / 0.1M acetic acid buffer solution (pH 4.0) in hyaluronidase (type IV-S from bovine testis, 500 NF unit / ml), and incubated at 37 ° C. for 20 minutes. 100 μl of 0.1 mg / ml of / 80 was added, followed by further incubation for 20 minutes at 37 ° C. 250 μl of hyaluronic acid (from rooster comb, 0.5 mg / ml) was added thereto, and the reaction was stopped at 37 ° C. for 40 minutes, followed by stopping the reaction with 100 μl of 0.4N NaOH. Subsequently, in order to quantify the amount of N-acetylhexasamine, 120 μl of 0.8 M potassium borate was added to the enzyme reaction solution, and after heating at 100 ° C. for 3 minutes, cooling to room temperature, 30 μl was taken out and 1% p − 180 µl of dimethylaminobenzaldehyde acetic acid was added and reacted at 37 ° C for 20 minutes. After cooling to room temperature, OD 590 nm was measured with a microplate reader EL-340 (BIO-TEK INSTRUMENT). And the inhibition rate (%) was computed according to the following formula | equation. The results are shown in Table 5 below.
    [66] Hyaluronidase Inhibition Rate (%) = (A-B) / A × 100
    [67] A; Absorbance at sample addition, B; Absorbance at Sample Addition
    [68] Herbal Medicine No.HyaluronidaseHerbal Medicine No.Hyaluronidase % Inhibition at 0.02%IC 50 μg / ml% Inhibition at 0.02%I C50 μg / ml 34. Leafy Grapes85.90.004833. Chrysanthemum41.70.0122 27.Golden80.10.0077Glycyrrhizin-0.0054
    [69] -: Not measured
    [70] As a result, it was examined at a concentration of 0.02%, and all three items of lobular grapes, golden chicks, and chrysanthemums were found to have a high inhibitory activity of 40% or more. In particular, lobular grapes had IC 50 values lower than those of glycyrazine, a positive control, and strong inhibition. Activity was confirmed.
    [71] Experimental Example 5: SOD activity test
    [72] It was measured by 96-well microplates using the SOD test Waco (Wako Pure Chemical) based on the nitroblue tetrazolium (NBT) reduction method.
    [73] 10 μl of the sample was added to 95 μl of the color developing reagent containing 0.24 M NBT and 0.4 M xanthine, and 95 μl of the enzyme solution (xanthine oxidase) was further added, followed by incubation at 37 ° C. for 30 minutes. Thereafter, the enzyme reaction was stopped with 100 µl of a reaction stopper solution (69 mM sodium dodecyl sulfate), and OD 562 nm was measured with a microplate reader EL-340 (BIO-TEK INSTRUMENT). A superoxide anion (O 2 − ) scavenging ratio was calculated according to the following formula using a sample in which purified water was added instead of an enzyme as a background and a sample in which a solvent was added instead of a sample as a control.
    [74] The results are shown in Table 6.
    [75] O 2 - Clearance (%) = (AB) / A × 100
    [76] A: absorbance of control group B: absorbance at sample addition
    [77] IC 50 values are O 2 - are shown in the sample concentration when erasure rate is revealed the 50%.
    [78] As a result, 57 herbal drugs with 30% or more SOD activity were found at 0.025% concentration. Especially, IC 50 value was higher than that of Asunak (gambir), which is a positive control of gold, Lasi splint and lobe. This low and strong SOD activity was confirmed.
    [79] Herbal Medicine No.SOD type action Herbal Medicine No.SOD type action% Clearance at 0.025%IC 50 μg / ml% Clearance at 0.025%IC 50 μg / ml 27.Golden100.834.571. Doohwa Hyanggo50.0- 35. Chrysanthemum100.271.618. Fossil Water49.8- 65. Lassi salted splint99.553.854. Chajeoncho49.0- 34. Leafy Grapes95.477.366. Gold Swordweed47.3- 9. Lobe90.954.539. Hojija47.0- 22. White leaf root79.782.375. Three Leaf Oga46.1- 19. Prohibited79.661.924. Stern45.360. Taiwan Shaoshou78.288.317. Ma'an45.2- 32. Agu74.486.170.43.6- 44. Mountain72.185.047. Yellow42.8- 64. Taiwan lantern70.690.021. Nanling Yew42.6- 50. Seogukcho69.0-4. Semi-arismic41.8- 36. Gold pomegranate65.3-7. Earthenware41.6- 46. Haeju Sangsan65.0-74. Dong Chuok Weed41.4- 58. Daegeulcho61.5-68. Earthen Bond41.0- 37. Union60.9-23. jade gold coin40.9- 31. Neck59.7-1. Crystalline Incense40.0- 73. James59.1-57. Stop Goku39.6- 2. First58.1-16. Beautiful woman39.4- 29. Daecheong58-41. The Golden Lamp39.2- 14. capping seconds56.5-33. Trifolium Grape37.2- 6. Verbena56.2-28. Intoxication37- 55. To order56.2-11.Hwabchae32.3- 69. Dosangcho54.5-52. Much sec31.9- 26. Seokchangpo53.0-10. Gossip31.2- 3. ring52.3-30. White Dragon Painting31.1- 72. Safflower52.3-43. Iron Monastery30.3- 63. River lights52.1-53. Yuzacho51.4-Melissa-50.5 40. cedar clove50.8-catechu-55.0
    [80] -: Not measured
    [81] Experimental Example 6: DPPH radical capture
    [82] (1) 50 μL of 0.2 M acetate buffer (pH5.5)
    [83] (2) 250 μM DPPH / ethanol 100 μL
    [84] (3) 100 μL of sample / 50% ethanol
    [85] (1) to (3) were put in a 96-hole multimicroplate (manufactured by NUNC), incubated at 30 ° C for 30 minutes, and then absorbance was measured at a wavelength of 515 nm with a microplate reader EL-340 (BIO-TEK INSTRUMENT). . The degree of activity was expressed by DPPH Radical Scavenging (%) obtained from the following equation. The results are shown in Table 7 below.
    [86] DPPH Radical Scavenging (%) = (A-B) / A × 100
    [87] A; Absorbance at sample addition, B; Absorbance at Sample Addition
    [88] IC 50 value = Test Subject Concentration with DPPH Radical Scavenging showing 50%
    [89] Herbal Medicine No.DPPH radical captureHerbal Medicine No.DPPH radical capture % Inhibition at 0.002%IC 50 μg / ml% Inhibition at 0.002%IC 50 μg / ml 60. Taiwan Shaoshou83.59.31. Crystalline Incense49.2- 65. Lassi salted splint82.28.263. River lights45.9- 35. Chrysanthemum77.52.644. Mountain44.2- 22. White leaf root76.45.16. Verbena42.7- 32. Agu75.77.243. Iron Monastery38.4- 9. Lobe75.65.345. Gyeancho37.7- 27.Golden75.311.424. Stern37.6- 31. Neck74.96.461. For milk37.2- 19. Prohibited74.510.414. capping seconds36.2- 36. Gold pomegranate73.214.647. Yellow35.5- 64. Taiwan lantern69.49.658. Daegeulcho34.7- 33. Trifolium Grape68.511.157. Stop Goku33.8- 46. Haeju Sangsan62.826.042. The Foul33.3- 2. First62.316.539. Hojija32.4- 29. Daecheong59.6-53. Yuzacho32.2- 37. Union57.8-3. ring31.8- 34. Leafy Grapes57.1-21. Nanling Yew30.8- 23. jade gold coin54.4-Ascorbic acid-4.1 17. Ma'an50.5-Glutathione-13.5 40. cedar clove49.9-
    [90] -: Not measured
    [91] As a result, there were 37 items of herbal medicines that showed 30% or more DPPH radical capture at a concentration of 0.002%. In particular, chrysanthemum had IC 50 values lower than that of ascorbic acid, a positive control, and strong DPPH radical capture. .
    [92] Summary: Herbal Extracts with Multiple Actions
    [93] The herbal extracts having all of the melanin production inhibitory, elastase inhibitory activity, hyaluronidase inhibitory activity, SOD-type action, DPPH radical scavenging action corresponded to chrysanthemum and golden family. Herbal extracts with melanin inhibition, elastase inhibitory activity, SOD-type action, and DPPH radical scavenging activity included Nanling Yew, Hojija, cedar clove, and stoppage. The medicinal herb extract with melanin inhibition, hyaluronidase inhibitory activity, SOD-type action, and DPPH radical scavenging action were included. In this way, it was confirmed that a single herbal medicine has a combination of whitening-anti-inflammatory-antioxidant, whitening-antioxidant, whitening-anti-inflammatory and antioxidant-anti-inflammatory.
    [94] As a herbal extract blended with an anti-aging agent, using a herbal medicine having a plurality of actions can be expected to have a multi-faceted effective action with a small number of herbal medicines, and each effect synergistically influences each other to increase anti-aging effect. Prescription is possible.
    [95] The following describes a typical embodiment incorporating the anti-aging composition according to the present invention in various formulations.
    [96] Example 1: lotion
    [97] The lotion of the composition shown in Table 8 was prepared using the extracts of chrysanthemum, golden, Lasi sapling, lobular grapes and Nanling Yew of the herbal medicine.
    [98] Example ingredientExample 1Example 2Example 3Example 4Example 5 (1) ethanol5.05.05.05.05.0 (2) 1,3-butylene glycol2.02.02.02.02.0 (3) hyaluronic acid0.20.20.20.20.2 (4) polyoxyethylene hardened castor oil0.050.050.050.050.05 (5) methyl paraoxybenzoate0.10.10.10.10.1 (6) spices0.10.10.10.10.1 (7) Chrysanthemum (No.35) extract2.0---- (7) Golden system (No. 27) extract-4.0--- (7) Lassi salted splint (No.65) extract--1.0-- (7) Leafy Grape (No. 34) Extract---0.02- (7) Nanling Yew Wah (No.21) Extract----0.01 (8) distilled waterRemainderRemainderRemainderRemainderRemainder
    [99] Manufacturing method: The lotion was obtained by melt | dissolving (3) and (7) in (8), adding (1), (2), (4), (5) and (6) to this, and fully stirring.
    [100] Example 2: Latex
    [101] The emulsions of the compositions shown in Table 9 were prepared using the extracts of chrysanthemum, golden, Lacy sapling, lobular grapes and Nanling Yew of the herbal medicine.
    [102] Example ingredientExample 6Example 7Example 8Example 9Example 10 (1) stearic acid2.02.02.02.02.0 (2) floating paraffin5.05.05.05.05.0 (3) squalene2.02.02.02.02.0 (4) sorbitan monostearate1.51.51.51.51.5 (5) polyoxyethylene (20) sorbitan monostearate2.02.02.02.02.0 (6) butyl paraoxybenzoate0.050.050.050.050.05 (7) glycerin2.02.02.02.02.0 (8) methyl paraoxybenzoate0.10.10.10.10.1 (9) spices0.150.150.150.150.15 (10) Chrysanthemum (No.35) extract5.0---- (10) Golden system (No. 27) extract-5.0--- (10) Lassi salted splint (No.65) extract--1.0-- (10) Leafy Grape (No. 34) Extract---0.2- (10) Nanling Yew Wah (No.21) Extract----0.1 (11) distilled waterRemainderRemainderRemainderRemainderRemainder
    [103] Manufacturing method: (7), (8), and (10) were added to (11), and emulsification was carried out by adding (1)-(6) at 80 degreeC to this, Then, (9) was added, it cooled to room temperature, Got it.
    [104] Example 3: Cream
    [105] Creams of the compositions shown in Table 10 were prepared using the extracts of chrysanthemum, golden, Lacy sapling, lobular grapes and Nanling Yew of the herbal medicine.
    [106] Example ingredientExample 11Example 12Example 13Example 14Example 15 (1) floating paraffin23.023.023.023.023.0 (2) vaseline7.07.07.07.07.0 (3) cetanol1.01.01.01.01.0 (4) stearic acid2.02.02.02.02.0 (5) beeswax2.02.02.02.02.0 (6) sorbitan monostearate3.53.53.53.53.5 (7) polyoxyethylene (20) sorbitan monostearate2.52.52.52.52.5 (8) butyl paraoxybenzoate0.050.050.050.050.05 (9) hyaluronic acid0.10.10.10.10.1 (10) 1,3-butylene glycol1.01.01.01.01.0 (11) methyl paraoxybenzoate0.10.10.10.10.1 12.Spice0.150.150.150.150.15 (13) Lactic acid bacteria culture medium5.05.05.05.05.0 (14) Chrysanthemum (No.35) extract0.2---- (14) Golden system extract (No. 27)-0.5--- (14) Lassi salted splint (No.65) extract--0.25-(14) Leafy Grape (No. 34) Extract---0.1- (14) Nanling Yew Wah (No.21) Extract----0.05 (15) distilled waterRemainderRemainderRemainderRemainderRemainder
    [107] Manufacturing method: (10), (11), (13) and (14) are added to (15), and (9) is disperse | distributed to this and a dispersion liquid is obtained. Then, this was emulsified by adding (1) to (8) at 80 ° C, after which (12) was added and cooled to room temperature to obtain a cream.
    [108] In this way, the basic cosmetic products of Examples 1 to 15 obtained by the respective prescription examples had excellent melanin production inhibitory, elastase inhibitory activity, hyaluronidase inhibitory activity, SOD type action, and DPPH radical trapping action, respectively. These basic cosmetics have excellent effects on lightening and whitening of pigmentation, blemishes, freckles and liver spots after sunburn and restoring and maintaining the skin's tension and elasticity by elastase inhibitory activity. It prevents and maintains a lively skin condition.
    [109] In addition, the anti-aging composition of the present invention has an antioxidant action, and by using them appropriately, cosmetics and the like which are excellent in safety and stable against oxidation can be produced, and the oxidation of the sebum component of the skin and the oxidation disorder of the skin, It is also effective for skin aging and protects the skin. Since the composition according to the present invention is a blending example of the herbal extract, it is excellent in feeling when used externally on the skin and is also very useful in beauty and medicine.
    [110] This time, the herbal extracts with whitening, anti-inflammatory and antioxidant activity found are extracts that have strong activity alone and also have a plurality of actions, which are useful for external skin preparations as anti-aging materials and have high stability. Long term continuous use is possible.
    [111] As described above, the present invention has an effect of obtaining a skin anti-aging composition which has a whitening effect, maintains the skin's tension and elasticity, enhances moisturizing to the skin, and has anti-inflammatory and anti-allergic effect. have.
    权利要求:
    Claims (8)
    [1" claim-type="Currently amended] Medically acceptable bases and / or excipients for skin dermatology, Ludwigia octovalvis, Anisomeles indica, Scutellaria rivularis, Lobelia chinensis, Una lobata, Verbena (Verbana officinalis), Cuscuta australis, Dichondra micrantha, Phyllanthus urinaria, Physalis angulata, Cleome gynandra, Ropepa indana, Letters formosydrocotyle ), Vernonia cinerae, Spilanthes acmella, Canna indica, Ipomoeapes-caprae, Chlorodendrum calamitosum, Drosera burmanni, Anoectochilus formosanus ), Wikstroemia indica, Eleeagnus oldhamii, Calendula (Mussaenda parviflora), Mesona procumbens, Aristolochia mollis, Agrarus gramineus, Cudrania cochinchinensis var. gerontogea, Clodendrum philippinum, Daecheong (Clerodendrum cyrtop) hyllum, Clodendrum paniculataum var.albifloraum, Boehmeria densiflora, Sapium sebiferum, Tetrastigma dentatum, Vitis thunbergii, Bahinhin champion (Bauhinia championi) Bredia oldhami, Staurogyne concinnula, Selaginella doederleinii, Lespedeza cuneata, Leafwig clove (Ludwigia hyssopifolia), Stellaia japonica, Sphenomerischusana, Iron flameula (tum) ), Sanhyang (Hyptis suaveolens), Kummerowia striata, Clowndendrum trichotomum, Vitex negundo, Changi (Xanthium strumarium var. japonica, Bidens pilosa var. minor, Gnaphalium affine, Emilia sonchifolia, Mimosa pudica, Euphorbia hirta, Plantago formosana, Cardiospermum halicacabum, Plumbago zeylanica, Torenia concolor var. formosona, Euphorbia formosana, Viola phillippica, Polygonum multiflorum var. hypoleucum, Ficus erecta var beecheyana, Kalanchoe spathulata, Mallothus repandus, Uncaria hirsuta, Rhus semialata var. roxburghiana, Rubia lanceolata, Safflower sageweed coccinea, Ixeris chinensis, Ixeris laevigata var.oldhami, Gordendrum inerme, Hyptis rhomboides, Callicarpa formosana, Yago (Aeginetia indica), Dongcheokdae It is selected from the group consisting of Praia nummularia and Acanthopanax trifoliatus Anti-aging composition, characterized in that it contains one or two or more plant extracts.
    [2" claim-type="Currently amended] Anisomeles indica, Urena lobata, Cuscuta australis, Dichondra, which have medically acceptable bases and / or additives, and especially melanin production as an anti-aging effect. micrantha, Physalis angulata, Cleome gynandra, Ropepa indica, Hydrocotyle formosana, Spilanthes acmella, Canna indica, Anoectochilus formosanus , Wikstroemia indica, Aristolochia mollis, Agrarus gramineus, Cudrania cochinchinensis var.gerontogea, Daecheong (Clerodendrum cyrtophyllum), Chrysanthemum (Bauhinia championi), Soliiiella doereder ), Lespideza cuneata, Leaf Wig Clove (Ludwigia hyssopifolia), Changi (Xanthium strumarium), Bidens pilosa var. Minor, Emilia sonchifolia, Plantago formosana, Plumbago zeylanica ), Geocorrosion (Torenia concolor var.formosona ), 1 type selected from the group consisting of Viola phillippica, Milkus (Ficus erecta var.beecheyana), Non-leafy grass (Kalanchoe spathulata), Rubia lanceolata, Salvia coccinea An anti-aging composition comprising at least two plant extracts.
    [3" claim-type="Currently amended] Medically acceptable bases and / or additives for skin external use, Phyllanthus urinaria, Wikstroemia indica, Cudrania cochinchinensis var. Gerontogea, which have an elastase inhibitory effect as an anti-aging effect, Boehmeria densiflora, Tetrastigma dentatum, Vitis thunbergii, Bauhinia championi, Bredia oldhami, Lespedeza cuneata, Ledwigia hyssopifolia Adiantum flabellulatum, Mimosa pudica, Cardiospermum halicacabum, Plumbago zeylanica, Torenia concolor var. Formosona, Polygonum multiflorum var. Hypoleucum, Taiwan lanterns Uncaria hirsuta), anti-aging composition, characterized in that it contains one or two or more plant extracts selected from the group consisting of Rhus semialata var. Roxburghiana.
    [4" claim-type="Currently amended] Medically acceptable bases and / or additives for skin use, and anti-aging effects of hyaluronidase, Cudrania cochinchinensis var.gerontogea, Vitis thunbergii, Bauhinia championi Skin anti-aging composition, characterized in that it contains one or two or more plant extracts selected from the group consisting of.
    [5" claim-type="Currently amended] Medically acceptable bases and / or additives for skin use, and free radicals as an anti-aging effect, Ludwigia octovalvis, Anisomeles indica, Scutellaria rivularis, Lobelia chinensis, Verbena officinalis, Cuscuta australis, Phyllanthus urinaria, Physalis angulata, Cleome gynandra, Vernonia cinerae, Canna indica, Hemp Ipomoea pes-caprae, Fossil water (Clerodendrum calamitosum), Drosera burmanni, Wikstroemia indica, Ellaeagnus oldhamii, Mussaenda parviflora, Mesona procumbens (Acorus gramineus), Golden family (Cudrania cochinchinensis var. , Tetrastigma dentatum, Vitis thunbergii, Bauhinia championi, Bream lodhami, Starogyne concinnula, Lespedeza cuneata, Ludwigia hyssopifolia, Stephania japonica, Adiantum flabellulatum, Hyptis suaveolens, Cleopadendrum trichotomum, Vitex negundo, Gnaphalium affine, Mimosa pudica, Euphorbia (Euphorbia hirta), Toorenia concolor var. formosona, Echohorbia formosana, Polygonum multiflorum var. hypoleucum, Moltus repandus, Uncaria hirsuta, Rhus semialata var. roxburghiana, Planatago for mosana, Cardiospermum halicacabum, Rubia lanceolata, Ixeris chinensis, Ixeris laevigata var.oldhami, Cledenden inerme, Hyptis rhomboides, two Anti-aging composition, characterized in that it contains one or two or more plant extracts selected from the group consisting of safflower (Callicarpa formosana), yago (Aeginetia indica), Prachu nummularia, Acanthopanax trifoliatus
    [6" claim-type="Currently amended] Medically acceptable bases and / or additives for skin use, antioxidants as anti-aging effects, Ludwigia octovalvis, Anisomeles indica, Scutellaria rivularis, Verbena officinalis, Phyllanthus urinaria, Vernonia cinerae, Ipomoea pes-caprae, Drosera burmanni, Wikstroemia indica, Ellaeagnus oldhamii, Mussaenda parviflora , Mesona procumbens, Cudenia cochinchinensis var.gerontogea, Daecheong (Clerodendrum cyrtophyllum), Boehmeria densiflora, Sapium sebiferum, Tetrastighun denbergi, t leaf grape (Vitis) Chrysanthemum (Bauhinia championi), Gemini (Bredia lodhami), Cochlear (Staurogyne concinnula), Hojiza (Lespedeza cuneata), Locuswigia hyssopifolia, Sphenomeris chusana, Adiantum flabellulatum (Hyptis suaveolena), Gyeancho (Kummerowia stri ata, Clodendrum trichotomum, Vitex negundo, Euphorbia hirta, Torenia concolor var.formosona, Euphorbia formosana, Polygonum multiflorum var. hypoleucum, Contains one or two or more plant extracts selected from the group consisting of Milkus (Ficus erecta Var. Beecheyana), Mollustus repandus, Uncaria hirsuta, and Rhus semialata Murp roxburghiana Skin anti-aging composition, characterized in that.
    [7" claim-type="Currently amended] A cosmetic material comprising the anti-aging composition according to claim 1.
    [8" claim-type="Currently amended] A skin external preparation containing the anti-aging composition according to claim 1.
    类似技术:
    公开号 | 公开日 | 专利标题
    US20150335692A1|2015-11-26|Oral preparation, injection preparation, external skin preparation and cosmetic method for preventing or improving wrinkles
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    同族专利:
    公开号 | 公开日
    BR0116098A|2003-12-30|
    TWI287997B|2007-10-11|
    JP2002179581A|2002-06-26|
    EP1352640A1|2003-10-15|
    US8101211B2|2012-01-24|
    US20040028643A1|2004-02-12|
    EP1352640A4|2008-09-10|
    BR0116098B1|2014-02-11|
    WO2002047656A1|2002-06-20|
    JP4880816B2|2012-02-22|
    KR100829846B1|2008-05-16|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    法律状态:
    2000-12-15|Priority to JP2000381813A
    2000-12-15|Priority to JPJP-P-2000-00381813
    2001-12-10|Application filed by 가부시끼가이샤 야구르트혼샤
    2001-12-10|Priority to PCT/JP2001/010782
    2003-07-22|Publication of KR20030061847A
    2008-05-16|Application granted
    2008-05-16|Publication of KR100829846B1
    优先权:
    申请号 | 申请日 | 专利标题
    JP2000381813A|JP4880816B2|2000-12-15|2000-12-15|Skin anti-aging agent|
    JPJP-P-2000-00381813|2000-12-15|
    PCT/JP2001/010782|WO2002047656A1|2000-12-15|2001-12-10|Compositions for retarding skin aging|
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